molecular beacons

Assay Instruments

A number of spectrofluorometric thermal cyclers and spectrofluorometric temperature-controlled plate readers that monitor the progress of amplification reactions (i.e., Polymerase Chain Reaction (PCR), Nucleic Acid Sequence Based Amplification (NASBA), Transcription Mediated Amplification (TMA), Rolling Circle Amplification (RCA) and Strand Displacement Amplification (SDA)) by monitoring changes in fluorescence are available and are compatible with molecular beacons. In addition, fluorospectrometers are available to monitor the fluorescence generation of molecular beacons with and without nucleic acid targets present.

              

Company

               

Model

           

On Line


Applied Biosystems


7300 & 7500


www.appliedbiosystems.com

Applied Biosystems

PRISM 7700 & 7900HT

www.appliedbiosystems.com

bioMerieux

NucliSens EasyQ

www.biomerieux.com

Bio-Rad

CFX96 & CFX384

www.bio-rad.com

Bio-Rad

Chromo 4

www.bio-rad.com

Bio-Rad

iCycler iQ 5

www.bio-rad.com

Bio-Rad

MiniOpticon

www.bio-rad.com

Cepheid

GeneXpert

www.cepheid.com

Cepheid

SmartCycler

www.cepheid.com

Corbett Research

Rotor-Gene 6000

www.corbettresearch.com

Idaho Technology

RapidCycler 2

www.idahotech.com

NanoDrop Technologies

ND-3300 Fluorospectrometer

www.nanodrop.com

Eppendorf

Mastercycler ep realplex

www.eppendorf.com

Roche Applied Science

LightCycler 1.5 and 2

www.roche-applied-science.com

Roche Applied Science

LightCycler 480

www.roche-applied-science.com

Stratagene

Mx3000P & Mx3005P

www.stratagene.com

 

 

 


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www www.molecular-beacons.org




Recent Publications from our group


Marras SAE, Bushkin Y, and Tyagi S (2019) High-fidelity amplified FISH for the detection and allelic discrimination of single mRNA molecules. Proceedings of the National Academy of Sciences USA, 128, 13921-13926





Marras SAE, Tyagi S, Antson D, and Kramer FR (2019) Color-coded molecular beacons for multiplex PCR screening assays. PLoS One 14: e0213906




Vargas DY, Marras SAE, Tyagi S, and Kramer FR (2018) Suppression of Wild-Type Amplification by Selectivity Enhancing Agents in PCR Assays That Utilize SuperSelective Primers for the Detection of Rare Somatic Mutations. The Journal of Molecular Diagnostics, 20, 415-427