molecular beacons

Licensing Program

Public Health Research Institute Properties, Inc. (PHRI) offers non-exclusive worldwide licenses for the molecular beacons technology in a variety of fields and for a variety of uses. A license under PHRI's patents includes rights to seven different patents and patent applications and further improvements to the technology.

A complete list of countries in which patent applications are filed and a complete list of countries in which patents are issued, including their issue and termination dates can be downloaded here.

Download Patents and Patent Applications

These patents can also be viewed and printed. Issued claims describe molecular beacon probes, kits, and assays. Patents that cover additional aspects of molecular beacons technology are pending. Foreign counterparts are issued or pending in Australia, Canada, China, Europe and Japan. Licensing income received by PHRI is used to support further research. Also, a license creates a collaborative relationship with the laboratory of Drs. Fred Russell Kramer, Sanjay Tyagi, and Salvatore Marras, the inventors of the technology.

For more information on the molecular beacons licensing program, please contact Dr. Fred Russell Kramer (; 1-973-854-3370.)

Products and Assays that Utilize Molecular Beacons Technology

  1. Custom molecular beacon probes
  2. Assay kits
  3. Performance of assays for a fee
  4. Performance of assays for internal quality control
  5. Assay instruments

Fields of Use for Molecular Beacons Technology

  1. Human in vitro diagnostics
    a. Testing for infectious agents
    b. Genetic testing
    c. Oncology
  2. Research
  3. GMO testing
  4. Food testing
  5. Veterinary diagnostics
  6. Hybrid seed production
  7. Agricultural infectious agents
  8. Forensics
  9. Paternity testing
  10. High-density probe arrays
  11. Industrial microbiology
  12. Blood products quality control
  13. Environmental pathogens

The fields of use are not limited to this list. New applications and fields for molecular beacons arise frequently.

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Recent Publications from our group

Marras SAE, Bushkin Y, and Tyagi S (2019) High-fidelity amplified FISH for the detection and allelic discrimination of single mRNA molecules. Proceedings of the National Academy of Sciences USA, 128, 13921-13926

Marras SAE, Tyagi S, Antson D, and Kramer FR (2019) Color-coded molecular beacons for multiplex PCR screening assays. PLoS One 14: e0213906

Vargas DY, Marras SAE, Tyagi S, and Kramer FR (2018) Suppression of Wild-Type Amplification by Selectivity Enhancing Agents in PCR Assays That Utilize SuperSelective Primers for the Detection of Rare Somatic Mutations. The Journal of Molecular Diagnostics, 20, 415-427